研究生导师简介

一般情况

姓名： 毕洪凯，性别：男                  

学科专业：药学化学

学历及学位：博士研究生

职称：教授

职务：南京医科大学基础医学院和附属逸夫医院教授，南京医科大学幽门螺杆菌研究中心主任。

研究方向

1.新型抗菌药物筛选与研发

2.幽门螺杆菌致病新机理

3.抗菌药物新靶点确证

近年发表代表性论文：(近5年)

1.JiangX,DuanY,ZhouB,GuoQ,WangH,HangX,ZengL,JiaJ,BiH*.TheCyclopropaneFattyAcidSynthaseMediatesAntibioticResistanceandGastricColonizationofHelicobacterpylori.JBacteriol.2019Sep20;201(20).pii:e00374-19. 

2.HuangY,HangX,JiangX,ZengL,JiaJ,XieY,LiF,BiH*.InVitroandInVivoActivitiesofZincLinolenate,aSelectiveAntibacterialAgentagainstHelicobacterpylori.AntimicrobAgentsChemother.2019May24;63(6).pii:e00004-19. 

3.HangX,ZengQ,ZengL,JiaJ*,BiH*.FunctionalReplacementoftheBioCandBioHProteinsofEscherichiacoliBiotinPrecursorBiosynthesisbyEhrlichiachaffeensisNovelProteins.CurrMicrobiol.2019May;76(5):626-636. 

4.QiaoY,YanJ,JiaJ,XueJ,QuX,HuY,DengZ,BiH*,ZhuD*.CharacterizationoftheBiosyntheticGeneClusterfortheAntibioticArmeniaspirolsinStreptomycesarmeniacus.JNatProd.2019Feb22;82(2):318-323. 

5.ShenS,HangX,ZhuangJ,ZhangL*,BiH*,ZhangL*.Aback-doorPhenylalaninecoordinatesthestepwisehexamericloadingofacylcarrierproteinbythefattyacidbiosynthesisenzymeβ-hydroxyacyl-acylcarrierproteindehydratase(FabZ).IntJBiolMacromol.2019May1;128:5-11.

6.BiH*,ZhuL,JiaJ,ZengL,CronanJE*.UnsaturatedFattyAcidSynthesisintheGastricPathogenHelicobacterpyloriProceedsviaaBacktrackingMechanism.CellChemBiol.2016Dec22;23(12):1480-1489. 

7.BiH*,ZhuL,JiaJ,CronanJE*.ABiotinBiosynthesisGeneRestrictedtoHelicobacter.SciRep.2016Feb12;6:21162. 

8.CaoDM,LuQF,LiSB,WangJP,ChenYL,HuangYQ*,BiHK*.ComparativeGenomicsofH.pyloriandNon-PyloriHelicobacterSpeciestoIdentifyNewRegionsAssociatedwithItsPathogenicityandAdaptability.BiomedResInt.2016;2016:6106029. 

9.BiH,YuY,DongH,WangH,CronanJE*.Xanthomonascampestris RpfBisafattyAcyl-CoAligaserequiredtocounteractthethioesteraseactivityoftheRpfFdiffusiblesignalfactor(DSF)synthase.MolMicrobiol.2014Jul;93(2):262-75. 

10.BiH*,ZhangC.IntegrationhostfactorisrequiredfortheinductionofacidresistanceinEscherichiacoli.CurrMicrobiol.2014Aug;69(2):218-24. 

11.BiH,ZhuL,WangH,CronanJE*.InefficienttranslationrenderstheEnterococcusfaecalisfabKenoyl-acylcarrierproteinreductasephenotypicallycryptic.JBacteriol.2014Jan;196(1):170-9. 

12.ZhuL#,BiH#,MaJ,HuZ,ZhangW,CronanJE*,WangH*.Thetwofunctionalenoyl-acylcarrierproteinreductasesofEnterococcusfaecalisdonotmediatetriclosanresistance.MBio.2013Oct1;4(5):e00613-13. 

13.BiH,WangH,CronanJE*.FabQ,adual-functiondehydratase/isomerase,circumventsthelaststepoftheclassicalfattyacidsynthesiscycle.ChemBiol.2013Sep19;20(9):1157-67. 

14.BiH,ChristensenQH,FengY,WangH,CronanJE*.TheBurkholderiacenocepaciaBDSFquorumsensingfattyacidissynthesizedbyabifunctionalcrotonasehomologuehavingbothdehydrataseandthioesteraseactivities.MolMicrobiol.2012Feb;83(4):840-55.